Phenothiazines + Antacids
- Antacids significantly decrease CPZ (for example) blood level & urinary excretion. Allow at least 2 hrs between administration of both drugs.
Phenothiazines/Butyrophenones + Levodopa
- Therapeutic response of levodopa is inhibited by dopamine receptor blockade of the antipsychotic agents. The use of antipsychotics in parkinsonism should be avoided.
Phenothiazines/Butyrophenones + Benztropine/Trihexphenidyl
- Prophylactic use of both agents may return the patient to previous psychotic stage. Avoid prophylactic use of antiparkinsonian agents in patients receiving antipsychotic drugs.
Phenothiazines + amphetamines/chlorphentermine/phenmetrazine/ methylphenidate
- Anorexigenic effects are inhibited. These CNS stimulants may aggravate schizophrenic symptoms. Phenothiazines inhibit central effects of CNS stimulants. No legitimate indication for simultaneous utilization of these two classes of drugs
Pages: 1 2