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Daflon tablets: uses, dosage, side effects and composition

Daflon  is a medication which comes in the form of film-coated tablets, containing a micronized purified flavonoid fraction.

The tablets are composed of two main active ingredients: Diosmin (90%) and Flavonoids expressed as hesperidin (10%).

Each tablet contains 500 mg of the micronized purified flavonoid fraction, with 450 mg of Diosmin and 50 mg of hesperidin.

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The composition also includes other inactive ingredients called excipients in sufficient quantities. These are necessary to form the film-coated tablet.

Uses of Daflon

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Daflon is indicated for the treatment of symptoms related to venolymphatic insufficiency, such as heavy legs, pain, and early morning restless legs.

It is also used for the treatment of functional symptoms associated with acute hemorrhoidal attacks.

Dosage and Method of Administration:

The recommended dosage for Daflon 500 mg is 2 tablets per day, divided into two doses – one at midday and one in the evening, taken during meal times.

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For acute hemorrhoidal attacks, the dosage is increased to 6 tablets per day for the first 4 days, followed by 4 tablets per day for the next 3 days.

Contra-Indications of Daflon

There are no specific contra-indications listed for DAFLON 500 mg. However, don’t take it if you react to any of its ingredients.

Special Warnings and Precautions for Use:

For acute hemorrhoidal attacks, the administration of Daflon should not be considered a substitute for the treatment of other anal disorders.

The treatment should be of short-term duration. If symptoms persist, a proctological examination is recommended.

Drug Interactions and Other Forms of Interaction:

No specific drug interactions or other forms of interaction are noted.

Pregnancy and Lactation:

In pregnancy, experimental studies in animals have not shown teratogenic effects. No adverse effects have been reported in humans to date.

Breastfeeding is not recommended due to the lack of data regarding excretion into breast milk.

Effects on the Ability to Drive and Use Machines:

There are no effects of Daflon on the ability to drive or use machines.

Side-Effects of Daflon

A few cases of minor gastrointestinal and neurovegetative disorders have been reported, but these did not require suspension of treatment.

Pharmacodynamic Properties:

Daflon exhibits venotonic and vascular protective properties. It acts on the return vascular system by reducing venous distensibility and stasis. In the microcirculation, it normalizes capillary permeability and enhances capillary resistance.

Clinical trials have confirmed the venotonic, venous tonic, and microcirculatory activities of Daflon. It has shown to increase venous tone, decrease the rate of venous emptying, and enhance capillary resistance.

Pharmacokinetics Properties:

After oral administration, Daflon is primarily excreted in feces, with about 14% excreted in urine. The elimination half-life is approximately 11 hours. The drug undergoes extensive metabolism, leading to the presence of various phenol acids in urine.

Conclusion

Daflon is a film-coated tablet containing a micronized purified flavonoid fraction with Diosmin and Flavonoids expressed as hesperidin.

It is used to treat symptoms related to venolymphatic insufficiency and acute hemorrhoidal attacks.

 

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