Description of Mpiravir Capsules
Mpiravir capsule is an oral antiviral drug for the treatment of corona virus disease.
It contains Molnupiravir as its active ingredient. It also contains inert ingredients called excipients in sufficient quantities.
Mpiravir comes as hard capsules containing 200 mg of Molnupiravir each.
In the future, we could have more dosage forms of Molnupiravir. These may include its tablets, syrup or powder for suspension.
How Mpiravir capsules work
This section discusses the mechanism of action of Molnupiravir.
Molnupiravir is a prodrug that is converted through metabolism to its active form called ribonucleoside triphosphate (NHC-TP).
It is first metabolised into ribonucleoside analogue, N-hydroxycytidine (NHC). The NHC is then distributed into human cells.
In the cells, NHC is phosphorylated to the active form of Molnupiravir which is NHC-TP as noted above.
The NHC-TP incorporates into viral RNA by the viral RNA polymerase.
The incorporation results in an accumulation of errors in the viral genome leading to inhibition of replication.
Uses of Mpiravir Capsules
Mpiravir Capsule is used orally for the treatment of mild to moderate Corona virus disease in adults.
Conditions for use:
- It is used in patients with a positive SARS-COV-2 diagnostic test
- The patients are to have at least one risk factor for developing severe illness
In the future, it may also be used for Covid 19 disease prevention and prophylaxis.
Dosage of Mpiravir Capsules
The dose of Mpiravir for adults is 800 mg taken by mouth 12 hourly for 5 days.
The dosage for patients below 18 years is not available.
This is because the safety and efficacy of Molnupiravir in patients below 18 years is not yet established.
No dosage adjustment is required in the elderly.
No dosage adjustment is equally required in patients with renal and hepatic impairments.
What to do after missing a dose
If you miss a dose, take it as soon as you remember it provided that 10 hours has not passed. After that, resume the normal dosing schedule.
If 10 hours has passed from the time you took the last dose, wait for the remaining hours minutes and take the next dose.
In other words, take the next dose at the regularly scheduled time.
On no account should you double the dose to make up for a missed dose.
How to take Mpiravir Capsules
Swallow the capsules with a sufficient amount of fluid.
Swallow them whole – do not open, crush or chew the capsules.
They can be taken with or without food.
Molnupiravir capsules should be administered immediately or soon as possible after a positive diagnosis of corona virus disease and within 5 days of symptom onset.
It is taken orally and two time in a day for 5 days. Two times daily administration means 12 hourly.
It is not known if taking Molnupiravir for more than 5 days will be more beneficial or not. It is still not known if it is safe or not to take it for more than 5 days.
Follow the instructions above on a missed dose.
Take the the missed dose as soon as you remember it if it is not more than 10 hours late.
Otherwise, wait and continue with the next dose at the regularly scheduled time.
The following are some side effects of Molnupiravir
You may experience other side effects other than those listed above.
The side effects are non serious.
Please report any serious side effect you experience immediately to your doctor or pharmacist while using this drug.
Drug Interactions with Mpiravir Capsules
It is not known if Mpiravir interacts with other drugs or foods.
This is because of limited available data on it.
Pregnancy and Lactation
There is no enough data to support the use of Molnupiravir Capsules in pregnant and breastfeeding women.
Animal studies however showed reproductive toxicity.
Therefore, it should not be used by pregnant women, breastfeeding mothers and women who wants to get pregnant.
Breastfeeding women are to wait for 4 days after taking the last dose before resuming to breast feed their babies.
Non-pregnant women of childbearing potential should use effective contraception while on Molnupiravir capsules and for 4 days after taking the last dose.
Men who wants to get their women pregnant are advised to wait for at least 5 days after treatment with Molnupiravir Capsules before doing so.
Where to buy Mpiravir Capsules
You can buy Mpiravir Capsules from pharmacies that stock it.
Note that you will need a valid prescription to be able to buy it.
Do not accept to buy it from online vendors as it may likely be fake.
Will Mpiravir Capsules make me weak and tired?
For now, we are not sure if they will make you weak and tired after taking them as enough data is not yet available.
However, some drugs make people weak and tired after use. So, watch yourself and report any serious side effects you notice to your doctor or pharmacist while on this drug.
Note however that dizziness is one of its side effects.