Description and Composition of Klovinal
Klovinal Pessary is a formulation specially made for the treatment of mixed vaginal infections.
It is a combination of different drugs and each Pessary contains the following active ingredients:
In addition to the above listed active ingredients, Klovinal pessary contains inactive ingredients called excipients in sufficient quantities.
Klovinal pessary is white to off white bullet shaped Pessaries. The bullet shape allows for easy insert into the vagina of both virgins and those who are sexually active.
Pharmacodynamics of klovinal pessaries
Clotrimazole is a broad spectrum antifungal agent available for topical or Intravaginal use. It is active against yeast and dermatophytes and also some action against Gram +ve bacteria, especially Staphylococci and against Trichomonas.
Clotrimazole acts by altering the permeability of fungal cell walls by interfering with cell wall lipids.
Metronidazole is active against several protozoa including Trichomonas Vaginalis. It is bactericidal.
It is used in the treatment of susceptible protozoal infections and in the treatment and prophylaxis of anaerobic infections.
Specific bacterial infections treated with Metronidazole include bacterial vaginosis (nonspecific vaginitis).
3. Lactobacillus Spores
The vagina is dynamic ecosystem that normally contains approximately 10 bacterial colony forming units per gram of vaginal fluid.
The normal bacterial flora is dominated by Lactobacilli. Lactic acids and other organic acids are metabolized from glycogen by the lactobacilli, maintaining the vaginal pH between 3.8 and 4.2.
The acidic enviroment inhibits the overgrowth of bacteria and other organisms with pathogenic potential.
Because of vaginal infections like bacterial vaginosis, trichomoniasis and vulvovaginal candidiasis, the Lactobacilli flora goes down and vaginal pH Increases to more than 4.5.
Because of anaerobic bacteria, musty or fishy odour starts.
Lactobacillus is in spore form. It is used to recolonize the vaginal flora and to maintain the vaginal pH between 3.8 to 4.2.
When applied topically Clotrimazole penetrates the epidermis but there is little if any systemic absorption has been reported following vaginal administration.
Absorption of Metronidazole from vaginal Pessaries has been reported to be poor. Lactobacillus sporogenes recolonize the vaginal flora.
Indications and Uses of Klovinal Pessary
Klovinal Pessary is indicated for the treatment of vaginal infections like trichomoniasis, bacterial vaginosis and vulvovaginal candidiasis.
Dosage of Klovinal Pessary
One Klovinal Pessary should be inserted into the vagina as deeply as possible once daily. It should be used for 6 days, preferably on retiring to bed at night.
Can Klovinal Pessary Be Used During Period (Menstruation)
Klovinal or any other pessaries should not be used during menstrual period due to the risk of the pessary being washed out by the menstrual flow.
Meanwhile, in a situation where you are already using it before your menstrual period started, switch to an oral treatment if available or continue with the Klovinal Pessary until you complete it as prescribed by your doctor.
When in doubt, always consult your healthcare provider.
Can a virgin use Klovinal Pessary
Virgins can use it and any other pessaries. They should carefully insert it through small openings in their vaginas.
Can Klovinal prevent pregnancy
Klovinal pessary is used for the treatment of vaginal infections like trichomoniasis, bacterial vaginosis and vulvovaginal candidiasis.
It does not prevent pregnancy. None of its components has a contraceptive effect.
To prevent pregnancy, please use any standard contraceptive method. This includes pills, implants, condoms etc.
Discuss with a doctor or a reproductive health provider to know the best contraceptive method for you.
Do not use Klovinal if you are pregnant unless your doctor prescribed it.
Using it during pregnancy is only allowed if the benefits outweigh its possible risk to the fetus or if your doctor feels that you genuinely need it.
How long does it take for Klovinal to dissolve
One pessary of Klovinal is inserted into the vagina once daily for six days. After insertion, it dissolves completely within 10 to 15 minutes.
Does Klovinal hurt when inserted
It does not hurt when inserted. Although, it has the following side effects in some persons:
- Mild burning sensation, irritation, stinging to vaginal area
- Local pruritus
Is Klovinal good for yeast infection?
Klovinal is good for the treatment of yeast infection. Yeast infection is also known as Vulvo-Vaginal Candidiasis.
Klovinal is used for its treatment because it contains an antifungal drug called clotrimazole as one of its components (active ingredients).
In addition to its use for yeast infection treatment, Klovinal also helps in preventing recurrent yeast infection.
This is made possible by one of its components called lactobacillus spores.
Klovinal price in Nigeria
The price of Klovinal in Nigeria is not fixed. This means that it varies across different states and pharmacies.
In Abuja for instance, a pack of Klovinal pessaries is sold between N3000 to N7000. In the same Abuja, you can still get it cheaper especially in remote areas like Dei Dei, Dutse Makaranta etc.
So to know the actual price of Klovinal in your area, visit a nearby pharmacy and ask them.
Contraindications: when is Klovinal not to be used?
Klovinal Pessary is contraindicated in patients known to be hypersensitive to topical imidazoles and any of its ingredients.
Warning and Precautions
If irritation or sensitivity developes with the use of Klovinal Pessary, treatment should be discontinued and appropriate therapy instituted.
If there is lack of response to Klovinal Pessary treatment, microbiological studies should be done to confirm the diagnosis and rule out other pathogens before instituting other course of antimycolytic therapy.
Pregnancy and lactation
Is Klovinal Pessary safe in pregnancy and breastfeeding women? Can it be used by these women without issues to their babies?
Klovinal pessary should only be given to pregnant or lactating women if benefits of its use in them outweigh the possible risk to the fetus.
Interaction: Can Klovinal Pessary be taking or used together with other drugs?
Antibiotics with activity against lactobacilli should be avoided.
Antibiotics containing metronidazole, and clotrimazole should be avoided equally.
Side effects of Klovinal pessary
Klovinal has some side effects. These are effects that are unwanted and not intended for its use. The side effects of Klovinal are mild and tolerable.
Please noted these 4 points before you continue reading:
- You may not have any of the side effects of Klovinal
- You may have just one or few of them.
- You may even have one that is not listed here. Individuals differ.
- Report any serious and life threating side effects to a doctor”
The side effects of Klovinal include the following:
- Mild burning sensation, irritation, stinging to vaginal area
- Local pruritus
In addition to the above common side effects of Klovinal, others include:
- Abdominal pain
- Bacterial infection
- Abnormal bleeding from the uterus. (Metrorrhagia)
- Breast pain
- Sore throat (Pharyngitis)
People react to drugs differently. Side effects of Klovinal are mild but some persons may be sensitive to any of its components.
Do not use Klovinal if you are sensitive to either clotrimazole, metronidazole or lactobacillus spores.
Please report any life threatening adverse effect to your doctor immediately you notice it
Over dosage of Klovinal
Data of anyone overdosing on klovinal is not available.
Storage: How to safely store Klovinal Pessary
Keep in a dry place, below 30°C. Protect from light. Keep out of reach and sight of children.
It is a Strip of 6 Pessaries packed in a carton along with leaflet.
How to use Klovinal Pessaries
- Wash your hands
- Do not open pessary if it seems soft, hold the foil wrapper under cold water or place it in refrigerator for few minutes to harden it before removing the wrapper
- Remove one pessary from the strip and hold it in fingertips
- Remove any foil or plastic wrapping stuck to the pessary.
- Sit or lie down with your knees bent and legs apart.
- Gently insert the pessary into the vagina as far as comfortably possible using your fingers.
- Wash your hands again.